Compstatin

SKU: orb1296668

Description

Compstatin is a 13-residue cyclic peptide that potently and specifically inhibits primate complement C3. It is proteolytically stable in baboon blood and inhibits the classical and alternative pathways with IC50 values of 63 µM and 12 µM, respectively. This inhibitor is used in research on inflammatory diseases, ischemia-reperfusion injury, and biocompatibility in both in vitro and primate in vivo models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 206645-99-0
• MW: 1550.77
• Purity: >99.99% (May vary between batches)
• Formula: C₆₆H₉₉N₂₃O₁₇S₂
• SMILES: CC[C@H](C)[C@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)C(C)C)C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
• Target: Complement System
• Solubility: DMSO:115 mg/mL (74.16 mM)

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Complement System, ComplementSystem, Compstatin, Inhibitor, inhibit

Compound Identifiers

PubChem CID

25082538