Compound TPX-0046

SKU: orb1685576

Description

TPX-0046 is a selective RET kinase inhibitor that suppresses RET autophosphorylation. It is utilized in cancer research, particularly for studying RET-driven malignancies in both cellular and animal models.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2411115-73-4
• MW: 424.43
• Purity: 99.94% (May vary between batches)
• Formula: C₂₁H₂₁FN₆O₃
• SMILES: C[C@H]1CNC(=O)C2=C3N=C4C(=CN3N=C2)O[C@H]5CCC[C@H]5N4CC6=C(O1)N=CC(=C6)F
• Target: c-RET
• Solubility: DMSO:Slightly soluble

Bioactivity

• In Vivo:
  Compound TPX-0046 (2-5 mg/kg; twice daily for 27 days) decreases tumor size in mice.
• In Vitro:
  Compound TPX-0046 (0.3-300 nM) inhibits p-RET (y905) in RET-driven cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RET, Compound TPX 0046, Compound TPX0046, Compound TPX-0046, cRET, CompoundTPX0046

Compound Identifiers

PubChem CID

146662764