Cart summary

You have no items in your shopping cart.

Compound 401

SKU: orb1304029

Description

Compound 401

Research Area

Molecular Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number168425-64-7
MW281.31
Purity99.76%
FormulaC16H15N3O2
SMILESO=c1cc(nc2c3ccccc3ccn12)N1CCOCC1
TargetDNA-PK
SolubilityDMSO:5.45 mg/mL (19.37 mM)

Bioactivity

Target IC50
DNA-PK:0.28 μM|mTOR:5.3 μM
In Vitro
Compound 401 shows activity against mTOR IC50 = 5.3 μM) but not p110α/p85α PI3K IC50 > 100 μM). Treatment of cells with Compound 401 block the phosphorylation of sites modified by mTOR-Raptor and mTOR-Rictor complexes (ribosomal protein S6 kinase 1 Thr389 and Akt Ser473, respectively.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

Inhibitor, inhibit, 2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one, DNA-dependent protein kinase, DNA-PK, DNAPK, Compound401, Compound-401, Compound 401

Similar Products

  • Casein kinase 1δ-IN-13 [orb2695457]

    345616-08-2

    299.35

    C15H13N3O2S

    25 mg, 100 mg, 50 mg
  • Compound 401 [orb3033187]

    >98%

    168425-64-7

    381.3

    C16H15N3O2

    25 mg, 5 mg
  • FK-401 [orb1740935]

    85476-59-1

    564.67

    C31H40N4O6

    25 mg, 100 mg, 50 mg
  • Compound 401 [orb1225971]

    >98% (HPLC)

    168425-64-7

    281.3

    C16H15N3O2

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 2 mg, 1 g, 500 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Compound 401 (orb1304029)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 70.00
5 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 100.00
10 mg
$ 100.00
25 mg
$ 160.00
50 mg
$ 270.00
100 mg
$ 380.00
200 mg
$ 520.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry