Compound 35

SKU: orb1298714

Description

Compounds 35 demonstrate potent inhibitory activity against Ebola (Mayinga) and Marburg (Angola) viruses in vitro. These small molecules are valuable research tools for studying filovirus entry and replication, supporting the development of antiviral strategies in biochemical and cellular assays.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2479465-67-1
• MW: 461.52
• Purity: 99.85% (May vary between batches)
• Formula: C₂₅H₃₀F₃N₃O₂
• SMILES: O=C(NC1=CC=C(N2CCC(C)CC2)C(C(F)(F)F)=C1)C3=CC=C(CN4CCOCC4)C=C3
• Target: Others
• Solubility: DMSO:6 mg/mL (13 mM)

Bioactivity

• In Vitro:
  Compounds 35 are superior inhibitors of Ebola (Mayinga) and Marburg (Angola) infectious viruses. Compounds 35 have shown good metabolic stability in plasma and liver microsomes (rat and human), and 32 did not inhibit CYP3A4 nor CYP2C9. These 4-(aminomethyl)benzamides are suitable for further optimization as inhibitors of filovirus entry, with potential to be developed as therapeutic agents for the treatment and control of Ebola virus infections.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Compound 35, Marburg (Angola), Ebola (Mayinga), VUN65671, VUN-65671, VUN 65671

Compound Identifiers

PubChem CID

154729054