Compound 3344 hydrochloride

SKU: orb1298301

Description

Compound 3344 hydrochloride is a small molecule inhibitor that disrupts KRAS-effector protein interactions with a binding affinity of 126 nM. It is a valuable research tool for investigating KRAS-driven signaling pathways in biochemical and cellular assays, supporting both in vitro and in vivo oncology research.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• MW: 426.94
• Purity: 99.89% (May vary between batches)
• Formula: C₂₄H₂₇ClN₂O₃
• SMILES: COC1=CC(C2=C3OCCOC3=CC=C2)=CC=C1NC4=CC=CC(CN(C)C)=C4.[H]Cl
• Target: Ras,Kras
• Solubility: DMSO:60 mg/mL (140.53 mM)

Bioactivity

• In Vitro:
  In vitro competition studies of 3344 hydrochloride binding to KRAS-G12V in waterLOGSY NMR show the anti-RAS scFv inhibits 3344 hydrochloride binding to KRAS. In view of the in vitro inhibition by the anti-RAS scFv of 3344 hydrochloride binding to RASand because the iDAb RAS interferes with BRET signal in cells, 3344 hydrochloride was used for validation of the BRET2 toolbox for RAS-effector PPI inhibitors.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KRAS, 2368246-78-8, 2368246-78-8 free base, 4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline hydrochloride(2368246-78-8 free base), Compound 3344 Hydrochloride, Compound 3344 hydrochloride, Compound 3344 hydrochloride (2368246-78-8 free base)

Compound Identifiers

PubChem CID

163285820