Compound 23

SKU: orb1298668

Description

This compound, known as PROTAC BRAF-V600E degrader-1, is a selective small molecule that targets the oncogenic BRAF-V600E mutant protein for degradation while sparing the wild-type BRAF protein. It serves as a valuable chemical tool for investigating targeted protein degradation in cancers harboring the V600E mutation, applicable in both cellular and in vivo preclinical research models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2417296-84-3
• MW: 1001.07
• Purity: 99.43% (May vary between batches)
• Formula: C₄₈H₅₄F₂N₁₀O₁₀S
• SMILES: FC1=C(N2C=3C(C(=C2)C=4C=NC=NC4)=NC(N(C)C5CCN(C(CCOCCOCCOCCNC6=C7C(C(=O)N(C7=O)C8C(=O)NC(=O)CC8)=CC=C6)=O)CC5)=CC3)C(F)=CC=C1NS(CCC)(=O)=O
• Target: PROTACs,Raf
• Solubility: DMSO:10 mM

Bioactivity

• Target IC50:
  B-Raf (V600E):2 nM (Kd)|B-Raf:2.4 nM (Kd)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Compound 23, A375, BRAF-V600E, B-Raf (V600E), anticancer, Inhibitor, inhibit, melanoma, HT-29, Raf, Raf kinases, PROTAC BRAF-V600E degrader-1, PROTACs, ubiquitin-proteasome system

Compound Identifiers

PubChem CID

146161288