Compound 1769-24-0

SKU: orb2900179

Description

2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1769-24-0
• MW: 160.17
• Purity: >98% (HPLC)
• Formula: C₉H₈N₂O
• SMILES: CC1=NC2=CC=CC=C2C(=O)N1
• Solubility: In Vitro: DMSO : 50 mg/mL (312.17 mM; Ultrasonic ) H2O : < 0.1 mg/mL (insoluble)

Bioactivity

• In Vivo:
  2-Methylquinazolin-4-ol (0.2-1 mg; i. g. ; for two days) inhibits ATCase in a dosedependent manner In vivo. Animal model: Mice. Dosage: 0.2 mg, 0.4 mg, 0.6 mg, 0.8 mg, 1 mg. Administration: Oral gavage, for two days. Result: Showed an inhibitory effect upon ATCase.
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• In Vitro:
  2-Methylquinazolin-4-ol inhibits ATCase in a concentration-dependent manner.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only