Complanatoside A

SKU: orb1222682

Description

Complanatoside A is a flavonol glycoside isolated from Astragalus complanatus.

Key Properties

• CAS Number: 146501-37-3
• MW: 642.5
• Purity: >98% (HPLC)
• Formula: C₂₇H₃₀O₁₈
• SMILES: c1(c(c(=O)c2c(cc(cc2o1)O)O)O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)c1ccc(cc1)O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO
• Target: S1P Receptor
• Solubility: In Vitro: DMSO : ≥ 35.7 mg/mL (55.56 mM)

Bioactivity

• In Vitro:
  A simple and sensitive LC-MS/MS method is developed for the determination of complanatoside A in rat plasma over the range of 2.3-575 ng/mL. Complanatoside A is extracted from plasma by a protein precipitation procedure, separated by LC and detected by MS/MS in positive electrospray ionization mode. The lower limit of quantification is established at 2.3 ng/mL. Intra- and inter-day precisions (LLOQ, low-QC, med-QC and high-QC) are less than 7.9%, and accuracies are between 94.0 and 105.1%. Matrix effect is acceptable (97.9-103.0%) and extraction recovery is reproducible (88.5-94.4%). Complanatoside A is stable in the investigated conditions. The method is applied to the pharmacokinetics of complanatoside A in rats.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

S1P Receptor