Colistin sulfate

SKU: orb1309253

Description

Colistin sulfate (CAS 1066-17-7) is a polypeptide antibiotic complex of Polymyxins E1 and E2, derived from Bacillus colistinus. It is widely used in research for studying antimicrobial mechanisms and combating multidrug-resistant Gram-negative bacterial infections in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology

Key Properties

• CAS Number: 1264-72-8
• MW: 1253.51
• Purity: 98.00%
• Formula: C₅₃H₁₀₀N₁₆O₁₇S
• SMILES: OS(O)(=O)=O.CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O
• Target: Cell wall,Autophagy,Antibiotic,Antibacterial
• Solubility: H2O:125 mg/mL (99.72 mM);DMSO:Insoluble

Bioactivity

• In Vivo:
  Colistin (2 μg/mL) exhibits broad-spectrum antibacterial activity, effectively inhibiting most strains of Escherichia coli and Pseudomonas aeruginosa, as well as all strains of the genera Enterobacter, Salmonella, Shigella, Pasteurella, Brucella, and Bordetella. Additionally, it is active against strains of the genera Moraxella, Serratia, and Providencia. In 225 strains of P. aeruginosa, the MIC90 and MIC50 of Colistin are 6.3 μg/mL and 1.6 μg/mL, respectively. In Acinetobacter baumannii, Colistin sulfate demonstrates concentration-dependent post-antibiotic effects.
• In Vitro:
  In mice, daily intramuscular injections of Colistin sulfate (15 mg/kg) result in granular degeneration in renal and hepatic epithelial tissues. Similarly, in piglets, daily intramuscular injections of Colistin sulfate (15 mg/kg) lead to significant neurotoxic effects.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1066-17-7, 1066-17-7 free base, Autophagy, Antibiotic, Bacterial, cell wall, Cell wall, Cellwall, Colistin sulfate, Colistin Sulfate, Colistin sulfate (1066-17-7 free base), Colistin, Inhibitor, inhibit, Polymyxin E, Polymyxin E Sulfate, Polymixin E Sulfate

Compound Identifiers

PubChem CID

91885449