Coenzyme Q9

SKU: orb1301680

Description

Coenzyme Q9 (Ubiquinone 9) is a naturally occurring component of human plasma, potentially derived from dietary sources or as an intermediate in CoQ10 synthesis. This small molecule is utilized in research applications investigating mitochondrial function, oxidative stress, and lipid metabolism in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 303-97-9
• MW: 795.23
• Purity: 99.47%
• Formula: C₅₄H₈₂O₄
• SMILES: COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O
• Target: Endogenous Metabolite,Apoptosis
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMF:10 mg/mL (12.57 mM);DMSO:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble)

Bioactivity

• In Vivo:
  Mutations in the gene that encodes Coenzyme Q9(CoQ9) are associated with encephalomyopathy and autosomal-recessive, neonatal-onset, primary CoQ10 deficiency.While in humans CoQ10 predominates, mice and C. elegans primarily rely on CoQ9 for electron transport through the mitochondrial respiratory chain and for antioxidant functions[2,3].
• In Vitro:
  Coenzyme Q9 were cardioprotective, as evidenced by their abilities to improve left ventricular performance and to reduce myocardial infarct size and cardiomyocyte apoptosis.
• Animal Research:
  Guinea pigs were randomly divided into three groups: groups I and II were fed CoQ 9 and CoQ10, respectively, for 30 days while group III served as control. After 30 days, the guinea pigs were sacrificed and isolated hearts were perfused via working mode were subjected to 30 min ischemia followed by 2 h of reperfusion. Cardioprotection was assessed by evaluating left ventricular function, ventricular arrhythmias, myocardial infarct size, and cardiomyocyte apoptosis. Samples of hearts were examined for the presence of CoQ9 and CoQ10.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CoQ 9, CoQ9, CoQ-9, Coenzyme Q9, Coenzyme Q-9, Coenzyme Q 9, chain, antioxidant, Apoptosis, amphipathic, inhibit, endogenous, electron, Endogenous Metabolite, EndogenousMetabolite, Human Endogenous Metabolite, Inhibitor, left, rodents, ventricular, Ubiquinone 9, Ubiquinone Q 9, Ubiquinone Q9, Ubiquinone Q-9, Ubiquinone9, Ubiquinone-9, transport

Compound Identifiers

PubChem CID

5280473