Coccinine

SKU: orb3141915

Description

Coccinine ((-)-Coccinine) is a weak inhibitor of SERT with an IC50 of 196.3 μM and a Ki of 106.8 μM, and P-gp with an IC50 of 0.96 mM. It demonstrates significant antitumor activity against various cancer cell lines, including breast cancer (MCF7, Hs578T, MDA-MB-231), colon cancer (HCT-15), and lung cancer (A549). Additionally, Coccinine is applicable in research involving tumors and neurological disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 485-57-4
• MW: 301.34
• Formula: C₁₇H₁₉NO₄
• SMILES: O(C)[C@@H]1C=C2[C@@]3(C=4C(C[N@@](C3)[C@]2(C[C@@H]1O)[H])=CC5=C(C4)OCO5)[H]
• Target: Serotonin Transporter,P-gp

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Serotonin Transporter,P-gp