CNX-774

SKU: orb1305746

Description

CNX-774 is a potent, orally bioavailable, and irreversible small molecule inhibitor of Bruton's tyrosine kinase (BTK) with sub-nanomolar inhibitory activity. It is a valuable research tool for investigating BTK-dependent signaling pathways in both cellular assays and animal models of autoimmune diseases and B-cell malignancies.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1202759-32-7
• MW: 499.5
• Purity: 99.11% (May vary between batches)
• Formula: C₂₆H₂₂FN₇O₃
• SMILES: CNC(=O)c1cc(Oc2ccc(Nc3ncc(F)c(Nc4cccc(NC(=O)C=C)c4)n3)cc2)ccn1
• Target: BTK
• Solubility: Ethanol:2 mg/mL (4 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.61 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:93 mg/mL (186.19 mM)

Bioactivity

• Target IC50:
  BTK:<1 nM
• In Vivo:
  In a cellular assay, CNX-774 targeted residue Cys-481, the ATP-binding site of BTK, thereby inhibiting its activity (IC50: 1-10 nM).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, CNX774, CNX-774, CNX 774, autoimmune, Bruton tyrosine kinase, BTK, Btk, B-cell, BCR

Compound Identifiers

PubChem CID

59174579