CNX-1351

SKU: orb1305881

Description

CNX-1351 is a covalent small molecule inhibitor that selectively targets the PI3Kα isoform. It is a valuable research tool for investigating PI3Kα-driven signaling pathways in oncology, applicable in both cellular and animal models of cancer.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1276105-89-5
• MW: 573.71
• Purity: 99.83% (May vary between batches)
• Formula: C₃₀H₃₅N₇O₃S
• SMILES: CC(C)=CC(=O)CCC(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2cccc3[nH]ncc23)CC1
• Target: PI3K
• Solubility: DMSO:5.74 mg/mL (10.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.74 mM)

Bioactivity

• Target IC50:
  PI3Kγ:3020 nM|PI3Kβ:166 nM|PI3Kα:6.8 nM|PI3Kδ:240.3 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, CNX 1351, CNX1351, CNX-1351, Phosphoinositide 3-kinase, PI3K, PI3Kα

Compound Identifiers

PubChem CID

58441401