Cnidilide

SKU: orb3179544

Description

Cnidilide is a natural alkyl phthalide compound that can be isolated from the rhizomes of Cnidium officinale. It reduces the production of NO and PGE2 by inhibiting LPS-induced expression of iNOS and COX-2. Additionally, Cnidilide suppresses the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. It specifically inhibits the phosphorylation of p38 MAPK and JNK, as well as the activation of downstream kinase MSK-1. Moreover, Cnidilide blocks signaling pathways by inhibiting the transcriptional activities of AP-1 and NF-κB. This compound is useful in the study of inflammatory diseases.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 3674-03-1
• MW: 194.27
• Formula: C₁₂H₁₈O₂
• SMILES: C(CCC)[C@H]1[C@@]2([C@](C(=O)O1)(C=CCC2)[H])[H]
• Target: JNK,Interleukin,NO Synthase,TNF,COX,p38 MAPK,NF-κB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

JNK,Interleukin,NO Synthase,TNF,COX,p38 MAPK,NF-κB