Cnidicin

SKU: orb1297418

Description

Cnidicin is a bioactive small molecule with demonstrated anti-allergic and anti-inflammatory properties, inhibiting mast cell degranulation and NO production (IC50 = 7.5 µM). It also suppresses the proliferation of various human cancer cell lines in vitro, including A549, SK-OV-3, SK-MEL-2, XF498, and HCT-15 cells, highlighting its potential for immunology and oncology research.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 14348-21-1
• MW: 354.4
• Purity: 99.49% (May vary between batches)
• Formula: C₂₁H₂₂O₅
• SMILES: CC(C)=CCOc1c2ccoc2c(OCC=C(C)C)c2oc(=O)ccc12
• Target: NOS,NO Synthase
• Solubility: DMSO:25 mg/mL (70.54 mM)

Bioactivity

• In Vitro:
  The hexane soluble part of the extract demonstrated a significant inhibition on the proliferation of cultured human tumor cells such as A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nervous system) and HCT-15 (colon) in vitro, whereas the remaining water soluble part exhibited poor inhibition. Intensive investigation of the hexane soluble part of the extract yielded six furanocoumarins, i.e. isoimperatorin, Cnidicin, imperatorin, oxypeucedanin, byakangelicol, oxypeucedanin hydrate, all of which exhibited a significant inhibition on cell proliferation in a dose-dependent manner
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, NOSynthase, NOS, NO Synthase, Inhibitor, Cnidicin

Compound Identifiers

PubChem CID

10043694