CNDAC hydrochloride

SKU: orb1218903

Description

CNDAC hydrochloride, a nucleoside analog, is a metabolite of the sapacitabine.

Key Properties

• CAS Number: 134665-72-8
• MW: 288.69
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₃ClN₄O₄
• SMILES: Cl.NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2C#N
• Target: Others
• Solubility: DMSO:123 mg/mL (426.06 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: CDF1 mice, P388 tumor model. Dosage: 20 mg/kg. Administration: Intraperitoneal injection, daily for 10 days. Result: Greatly increased the survival time and survival rate.
• In Vitro:
  Cell Viability Assay Cell line: Rad51D-deficient 51D1, Rad51D-complemented 51D1.3, wild-type AA8 and XRCC3-deficient irs1SF CHO cells Concentration: 0-1 μM. Incubation time: 24 h. Result: Inhibited cell survival with IC50s of 0.006, 0.32, 0.48 and 0.0053 μM against Rad51D-deficient 51D1, Rad51D-complemented 51D1.3, wild-type AA8 and XRCC3-deficient irs1SF cell lines, respectively. Cell Proliferation Assay Cell line: HL-60 and THP-1 cells. Concentration: 0-100 μM. Incubation time: 3 days. Result: Inhibited proliferation with IC50s of 1.5832 μM and 0.84 μM against HL-60 and THP-1 cells, respectively. Apoptosis Analysis Cell line: HL-60 and THP-1 cells. Concentration: 0, 0.5, 1, 2, 3, 4, 5 and 10 μM Incubation time: 3, 4, 5, and 6 days. Result: Induced apoptosis in both cells. Cell Cycle Analysis Cell line: HCT116. Concentration: 6 μM. Incubation time: 48 h. Result: 36 and 36% of cells were arrested in late-S and G2/M phases, respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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