CMPF

SKU: orb1740990

Description

CMPF is a small molecule inhibitor of microtubule proteins, used as a research tool in oncology studies. It is applied in both in vitro cell-based assays and in vivo models to investigate mechanisms of tumor cell proliferation and mitotic arrest.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 86879-39-2
• MW: 240.25
• Purity: 99.88% (May vary between batches)
• Formula: C₁₂H₁₆O₅
• SMILES: C(CC(O)=O)C1=C(C(O)=O)C(C)=C(CCC)O1
• Target: Microtubule Associated,Endogenous Metabolite
• Solubility: Ethanol:27 mg/mL (112.38 mM);DMF:27 mg/mL (112.38 mM);DMSO:27 mg/mL (112.38 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.32 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  CMPF is highly albumin-bound and accumulates in the serum of uremic patients to concentrations in excess of 0.2 mM. Its primary effect is to inhibit cellular transport and subsequent deiodination of thyroxine (T4).
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• In Vitro:
  CMPF is tightly bound to albumin but only moderately inhibits T4 binding in a direct manner (10-14% at 0.3 mM). However, CMPF effectively displaces competitive T4 binding molecules from albumin, such as acidic drugs and free fatty acids. Therefore, CMPF may indirectly influence T4 binding to albumin by increasing the serum concentration of competitive binding molecules, particularly free fatty acids such as oleic acid.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Microtubule Associated, MicrotubuleAssociated, Tubulin

Compound Identifiers

PubChem CID

123979