CMPD1

SKU: orb1308436

Description

CMPD1 is a potent small molecule inhibitor that selectively blocks MK2 phosphorylation by targeting the p38 MAPK pathway in a non-ATP-competitive manner, with an apparent Ki of 330 nM. This compound is a valuable research tool for studying inflammation and cellular stress responses in both in vitro and in vivo experimental models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 41179-33-3
• MW: 349.4
• Purity: 99.67% (May vary between batches)
• Formula: C₂₂H₂₀FNO₂
• SMILES: Oc1ccc(NC(=O)CCCc2ccc(cc2)-c2ccccc2F)cc1
• Target: MAPK
• Solubility: DMSO:55 mg/mL (157.41 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.72 mM)

Bioactivity

• Target IC50:
  MK2:(Kiapp)330 nM
• In Vitro:
  CMPD1 exhibits selective activity within glioblastoma cells by inhibiting tubulin polymerization, crucial for cell division. Contrarily, it does not affect p38 MAPK-mediated phosphorylation of substrates MBP and ATF2, indicating specificity in its action. Furthermore, it induces mitotic arrest and apoptosis in U87 cells, highlighting its potential therapeutic implications in targeting cancer cell proliferation and survival.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MK2, MK2 phosphorylation, Mitogen-activated protein kinase activated protein kinase 2, inhibit, Inhibitor, MAP kinase activated protein kinase 2, MAPK activated protein kinase 2, MAPKAPK2 (MK2), MAPKAP kinase 2, CMPD1, CMPD-1, CMPD 1

Compound Identifiers

PubChem CID

11382492