CMC-Na (Viscosity:800-1200 mPa.s)

SKU: orb1307098

Description

Sodium carboxymethyl cellulose (CMC-Na) is a non-toxic, water-soluble polymer with a viscosity of 800-1200 mPa.s. It is widely employed in biomedical research as a safe vehicle for drug administration in both in vivo animal studies and in vitro experiments to enhance compound solubility and delivery.

Key Properties

• CAS Number: 9004-32-4
• MW: 354.375
• Formula: C₁₆H₂₇NaO₇
• SMILES: [Na+].CC1CCC(O)OC1COCC1CCCC(CCC(=O)O[O-])O1
• Target: Others
• Solubility: DMSO:insoluble;H2O:10 mg/mL (28.22 mM)

Bioactivity

• Target IC50:
  female mice (LD50):14 g/kg
• In Vivo:
  METHODS: To test the antitumor activity in vivo, AMG-510 (30 mg/kg in 0.5% Sodium carboxymethyl cellulose) was administered by gavage once a day for four weeks to Balb/C nude mice harboring the human lung cancer tumor H358. RESULTS: AMG-510 inhibited the growth of H358 tumor. METHODS: To test the antitumor activity in vivo, cediranib (5 mg/kg in 5% Sodium carboxymethyl cellulose) was administered by gavage to C57BL/6J mice bearing the mouse colorectal cancer tumor MC38 five times a week for eight days. RESULTS: Cediranib inhibited MC38 tumor growth.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CMC-Na, CMC-Na (Viscosity:800-1200 mPa.s), Sodium carboxymethyl cellulose (Viscosity:800 1200 mPa.s), Sodium carboxymethyl cellulose (Viscosity:8001200 mPa.s), Sodium carboxymethyl cellulose, Viscosity:800-1200 mPa.s

Compound Identifiers

PubChem CID

131674687