CM-272

SKU: orb1299991

Description

CM-272 is a potent small molecule inhibitor targeting both G9a histone methyltransferase and DNA methyltransferases (DNMTs). It is utilized in epigenetic research for studying cancer biology and has demonstrated activity in both cellular assays and in vivo animal models of hematological malignancies.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 1846570-31-7
• MW: 478.63
• Purity: 97.83% (May vary between batches)
• Formula: C₂₈H₃₈N₄O₃
• SMILES: COc1cc2c(NC3CCN(C)CC3)cc(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1
• Target: Histone Methyltransferase,Apoptosis,DNA Methyltransferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.89 mM);DMSO:96 mg/mL (200.57 mM);Ethanol:96 mg/mL (200.57 mM)

Bioactivity

• Target IC50:
  DNMT1:382 nM|G9a:8 nM|DNMT3B:1200 nM (IC50)|DNMT3A:85 nM|GLP:2 nM
• In Vivo:
  CM-272 (2.5 mg/kg; intravenous injection; daily; for 28 days; female Rag2 / γc / mice) treatment significantly prolongs survival of CEMO-1 cells xenogeneic models.Induced a statistically significant increase in overall survival (OS) in mice.
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• In Vitro:
  CM-272, inhibits cell proliferation and promotes apoptosis, inducing interferon-stimulated genes and immunogenic cell death. CM-272 significantly prolongs survival of AML, ALL and DLBCL xenogeneic models.
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• Cell Research:
  Cell Line:CEMO-1, MV4-11 and OCI-Ly10 cell lines. Concentration:125 nM, 250 nM, 500 nM (CEMO-1 cells); 135 nM, 270 nM, 540 nM (MV4-11 cells); 100 nM, 400 nM, 1000 nM (OCI-Ly10 cells). Incubation Time:12 hours, 24 hours, 48 hours and 72 hours
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• Animal Research:
  CM-272 (2.5 mg/kg; intravenous injection; daily; for 28 days; female Rag2 / γc / mice) treatment significantly prolongs survival of CEMO-1 cells xenogeneic models. Animal Model:Female BALB/Ca-Rag2 / γc / mice (6–8-week-old) with CEMO-1 cells. Dosage:2.5 mg/kg. Administration:Intravenous injection; daily; for 28 days
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CM272, CM-272, CM 272, DNMTs, DNMT3B, DNMT3A, DNMT1, DNAMethyltransferase, DNA Methyltransferase, DNA MTases, DNA methyltransferase (DNMT), anti-tumour, Apoptosis, immunogenic, inhibit, epigenetics, G9a, GLP, H3K9me2, Inhibitor, HistoneMethyltransferase, Histone Methyltransferase, substrate-competitive

Compound Identifiers

PubChem CID

118607432