Cltrinin

SKU: orb3054105

Description

Citrinin is a mycotoxin that causes contamination in the food and is associated with different toxic effects. Citrinin also possesses a broad spectrum of bioactivities, including antifungal, antibacterial, and potential anticancer and neuroprotective effects in vitro.

Key Properties

• CAS Number: 518-75-2
• MW: 250.25
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₄O₅
• Solubility: DMSO : 50 mg/mL (199.80 mM; ultraphonic; )

Bioactivity

• In Vivo:
  Animal model: Female BALB/c mice aged seven weeks old. Dosage: 1, 5, or 10 mg/kg. Administration: Oral gavage (i. g.); 14 days. Result: Significantly reduced the populations of F4/80+ cells and CD19+ cells in spleen and MLN. Increased the populations of CD4+, CD8+ and CD4+CD25+Foxp3+ cells in MLN. Increased the populations of CD8+ cells and decreased the populations of CD19+ cells in intra-epithelial, lamina propria and Peyer’s patches lymphocytes. Reduced IgM antibody production in serum. Increased the ratios of Bax/Bcl-2 in the spleen. Up-regulated the expression of Atg5, Beclin-1 and TLR 2 in the spleen. Animal model: DMBA treated swiss albino female mice aged 6-7 weeks old (25-30 g). Dosage: 2 mg/kg. Administration: Oral administration (p.o.); 3 weeks. Result: Reduced the weight of both breasts, and reduced cell proliferation in the breast. Did not cause necrosis in the cells, the characteristics of the carcinoma such as intraductal calcification, injured tissue, fibrosed with ductal hyperplasia, and histopathological characteristics indicative of preneoplasia still remained. Decreased genotoxic damage, damage index and damage frequency in breast and non-tumor cells induced by DMBA. Did not increase micronuclei or chromosomal bridge formation in hepatocytes of the animals.
• In Vitro:
  Apoptosis Analysis Cell line: Splenocytes and MLN cells from a SPF mouse ages 7 seven weeks old. Concentration: 1, 5 and 10 μg/mL. Incubation time: 6 h. Result: Significantly increased the number of late apoptotic cells, but not in early apoptotic cells. Western blot analysis. Cell line: Splenocytes. Concentration: 1, 5 and 10 μg/mL. Incubation time: 6 h. Result: Decreased the level of Bcl-2, and the expression of Bax was not affected.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only