CLT-28643

SKU: orb1738112

Description

CLT-28643

Research Area

Signal Transduction

Key Properties

• CAS Number: 1153631-91-4
• MW: 351.36
• Purity: 99.89%
• Formula: C₁₉H₁₇N₃O₄
• SMILES: O=C(O)C1=CN=C2C=CC(=CC2=C1NC3=CC=C(OC)C=C3)C(=O)NC
• Target: Integrin

Bioactivity

• In Vivo:
  In male C57BL/6 mice fed a high-fat-high-sucrose (HFHS) diet for 10 weeks, CLT-28643 (75 mg/kg; oral gavage; twice daily for 4 weeks) was administered to evaluate its cardiometabolic effect. CLT-28643 improved cardiac function by reversing the HFHS diet-induced elevation in heart rate, suggesting enhanced cardiovascular performance.
• In Vitro:
  In H9C2 cardiomyocytes, CLT-28643 (3 hours) was used to assess its effect on insulin signaling under metabolic stress, CLT-28643 prevented high glucose and palmitate-induced insulin resistance by significantly increasing the phosphorylated Akt (Ser473) to total Akt ratio, indicating restored insulin sensitivity.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CLT 28643, CLT28643, CLT-28643, ICI 204879 HCl, ICI204879 HCl, ICI-204879 hydrochloride

Compound Identifiers

PubChem CID

42596938