ClpP activator-2

SKU: orb3211413

Description

ClpPactivator-2 (Compound GU18) serves as a ClpP activator with a binding affinity (Kd) of 5.01 μM for HsClpP. It enhances the proteolytic activity of HsClpP and facilitates the degradation of α-casein, exhibiting an EC50 of 1.09 μM. Additionally, ClpPactivator-2 induces mitochondrial reactive oxygen species (ROS) accumulation, causing structural and functional mitochondrial damage. The compound demonstrates significant in vivo activity against multiple myeloma.

Key Properties

• CAS Number: 3036751-71-7
• MW: 483.31
• Formula: C₂₂H₁₉Cl₂F₃N₄O
• SMILES: O=C1N=C(NC2=C1CN(CC3=CC=C(Cl)C(Cl)=C3)CC2)NCC4=CC=C(C=C4)C(F)(F)F
• Target: Protease,Mitochondrial Metabolism,ROS

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Protease,Mitochondrial Metabolism,ROS