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Catalog Number | orb2814500 |
---|---|
Category | Small Molecules |
Description | Clozapine (HF 1854) dihydrochloride is utilized for researching psychiatric disorders. This compound exhibits high affinity for numerous neuroreceptors and acts as an effective antagonist of dopamine receptors, with a Ki value of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor, with Ki values of 9.5 nM and 4 nM, respectively. Additionally, Clozapine is a selective agonist of the muscarinic M4 receptor (EC50 = 11 nM). |
MW | 399.75 |
CAS Number | 2711603-38-0 |
Formula | C18H21Cl3N4 |
SMILES | ClC1=CC=C2NC3=C(C(N4CCN(CC4)C)=NC2=C1)C=CC=C3.Cl.Cl |
Storage | -20°C |
Note | For research use only |
98.11% | |
2250025-93-3 | |
452.2 | |
C18H22Cl4N4O |