Clotrimazole

SKU: orb1310546

Description

Clotrimazole

Research Area

Cell Biology, Infectious Disease & Virology

Key Properties

• CAS Number: 23593-75-1
• MW: 344.84
• Purity: 99.89%
• Formula: C₂₂H₁₇ClN₂
• SMILES: Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1
• Target: Autophagy,Antifection,Antifungal,Antibiotic,Antibacterial
• Solubility: Ethanol:64 mg/mL (185.59 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.9 mM);DMSO:36.43 mg/mL (105.64 mM)

Bioactivity

• In Vivo:
  In the CRI-G1 whole-cell of a rat insulinoma cell line, Clotrimazole antagonizes ADP-ribose-activated and single-channel currents. Clotrimazole effectively and rapidly inhibits parasite growth across five different strains of the malignant malaria protozoan. In HEK-293 cells expressing recombinant human TRPM2, Clotrimazole inhibits ADP-ribose-activated currents. At 2 mM concentration, Clotrimazole completely suppresses parasite replication, resulting in the destruction of host cells. Furthermore, Clotrimazole at concentrations ranging from 3 mM to 30 mM entirely inhibits TRPM2-mediated currents.
• In Vitro:
  Intradermal injection of Clotrimazole in mice stimulates capsaicin-sensitive and mustard oil-sensitive trigeminal neurons, inducing nocifensive behavior and thermal hyperalgesia. In TRPV1 knockout mice, Clotrimazole-induced pain behavior is inhibited by the TRPV1 antagonist BCTC [1,2,3,4-tetrahydro-6-trichloromethyl-pyrimidine-2-one].

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, FB 5097, FB5097, FB-5097, Fungal, Antibiotic, Bacterial, Autophagy, BAY b 5097, 14-α Demethylase, Clotrimazole

Compound Identifiers

PubChem CID

2812