Senicapoc

SKU: orb1225417

Description

A potent, selective Gardos channel blocker that blocks Ca(2+)-induced rubidium flux from human RBCs (IC50=11 nM) and inhibits RBC dehydration (IC50=10-50 nM); shows greater potency and selectivity than Clotrimazole; increases RBC K(+) content and hematocrit (Hct), decreases corpuscular hemoglobin concentration (MCHC) in a transgenic mouse model of sickle cell disease (SAD); orally active.Other Indication Phase 3 Discontinued.

Key Properties

• CAS Number: 289656-45-7
• MW: 323.336
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₅F₂NO
• SMILES: C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)C(=O)N
• Target: Potassium Channel
• Solubility: 10 mM in DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ICA-17043

Quick Database Links

Gene Symbol

Potassium Channel