Clofibrate

SKU: orb1309070

Description

Clofibrate is a synthetic aryloxyisobutyrate derivative that acts as a lipid-lowering agent. It is used in biochemical research to study peroxisome proliferator-activated receptor (PPAR) alpha agonism and lipid metabolism in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 637-07-0
• MW: 242.70
• Purity: 98.77% (May vary between batches)
• Formula: C₁₂H₁₅ClO₃
• SMILES: CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1
• Target: PPAR
• Solubility: DMSO:50 mg/mL (206.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.24 mM)

Bioactivity

• Target IC50:
  PPARα (human):55 μM(ec50)|PPARγ (human):500 μM (ec50)|PPARα (murine):50 μM (ec50)|PPARγ (murine):500 μM (ec50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Clofibrate, Clofibrato, Clofibratum, Ethyl clofibrate, PPARα, PPAR

Compound Identifiers

PubChem CID

2796