Clofazimine

SKU: orb1225740

Description

Clofazimine is a fat-soluble iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial drugs to treat AIDS and Crohn's disease.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2030-63-9
• MW: 473.4
• Purity: >98% (HPLC)
• Formula: C₂₇H₂₂Cl₂N₄
• SMILES: CC(C)N=C1C=C2C(=NC3=CC=CC=C3N2C4=CC=C(C=C4)Cl)C=C1NC5=CC=C(C=C5)Cl
• Target: DNA Alkylator
• Solubility: DMSO: 5 mg/mL (10.56 mM)

Bioactivity

• In Vivo:
  Animal model: Female BALB/c mice (age 6–8 weeks, mass 18–20 g). Dosage: 100, 50, 25, 12.5, 6.25, 3.125 or 1.5625 mg/kg. Administration: Oral gavage (p.o.), once per day for 14 d. Result: Exhibited an increase of the lung bacterial load during the first 7 days of treatment, and decreased the CFU counts in the lungs of mice after 10 days of treatment. Significantly declined the lung CFU counts in 100 or 50 mg/ kg group at 14th day.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 141046

Quick Database Links

Gene Symbol

DNA Alkylator