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Clofarabine-5'-triphosphate

SKU: orb2814588

Description

Clofarabine-5'-triphosphate, the active phosphorylated metabolite of the anticancer agent Clofarabine, is generated intracellularly by deoxycytidine kinase. It functions as a potent inhibitor of DNA synthesis and repair, making it a critical tool for studying nucleotide metabolism and cytotoxicity in leukemia and solid tumor research, both in vitro and in vivo.

Research Area

Cell Biology, Molecular Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number134646-41-6
MW543.62
FormulaC10H14ClFN5O12P3
SMILESF[C@@H]1[C@H](N2C=3C(N=C2)=C(N)N=C(Cl)N3)O[C@H](COP(OP(OP(=O)(O)O)(=O)O)(=O)O)[C@H]1O
TargetDNA/RNA Synthesis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Similar Products

  • Clofarabine-5'-triphosphate [orb533229]

    ≥ 95% (HPLC)

    167620-89-5

    Theoretical MW: 543.62 g/mol (free acid); Detected MW: 542.95 g/mol (free acid)

    C10H14ClFN 5O12P3

    5 μmol
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Key Properties

No computed properties available.

Protocol Information