CLK-IN-T3

SKU: orb1308442

Description

CLK-IN-T3 is a potent and selective small molecule inhibitor of CLK1, CLK2, and CLK3 kinases, with respective IC50 values of 0.67 nM, 15 nM, and 110 nM. It is a valuable research tool for studying CLK kinase biology and has demonstrated anti-proliferative effects in various cancer cell lines in vitro.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2109805-56-1
• MW: 482.58
• Purity: 99.61% (May vary between batches)
• Formula: C₂₈H₃₀N₆O₂
• SMILES: CN1CCN(CC1)C(=O)C(C)(C)c1ccc(cc1)C(=O)Nc1cn2cc(ccc2n1)-c1ccncc1
• Target: CDK,DYRK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.07 mM);DMSO:4.5 mg/mL (9.32 mM)

Bioactivity

• Target IC50:
  CLK3:110 nM|DYRK1B:230 nM|CLK1:0.67 nM|DYRK1A:260 nM|CLK2:15 nM
• In Vitro:
  CLK-IN-T3 (0.5, 1.0 μM) decreases the phosphorylation of CLK-targeted SR proteins and CLK proteins increase slightly. CLK-IN-T3 (0.1, 0.5, 1.0, 5.0, 10.0 µM) results in mild cell cycle arrest at the G2/M boundary with a long-duration of 24 h. CLK-IN-T3 inhibits DYRK1A and DYRK1B with IC50s of 260 and 230 nM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, kinase, CDC-like, CDK, CLK IN T3, CLK, CLK1, CLK2, CLK3, CLKINT3, CLK-IN-T3, CLK-IN-T-3, Cyclin dependent kinase, Dual specificity tyrosine regulated kinase, Dual specificity tyrosine phosphorylation regulated kinase, DYRK1A, DYRK1B, DYRK, anti-cancer, activity, stable

Compound Identifiers

PubChem CID

132585205