Clindamycin hydrochloride

SKU: orb1300760

Description

Clinimycin HCl is the hydrochloride salt of clindamycin, a semi-synthetic antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit. This solid compound is supplied in capsule form and is widely used in research for studying anaerobic infections and antibiotic mechanisms in both in vitro and in vivo models.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 21462-39-5
• MW: 461.44
• Purity: 99.80%
• Formula: C₁₈H₃₃ClN₂O₅S·HCl
• SMILES: Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@H](C)Cl)[C@H]1O[C@H](SC)[C@H](O)[C@@H](O)[C@H]1O
• Target: Antibacterial,Antibiotic
• Solubility: DMSO:75 mg/mL (162.53 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.33 mM)

Bioactivity

• In Vivo:
  Clindamycin hydrochloride is rapidly absorbed orally in dogs, exhibiting a mean absorption time (MAT) of 0.87 hours and a bioavailability of 72.55%. It shows a total clearance (CL) rate post intravenous (IV) and oral administration of 0.503 and 0.458 L/h/kg respectively, and reaches a steady-state volume of distribution (IV) of 2.48 L/kg, indicating extensive distribution throughout the body's fluids and tissues. Serum concentrations of clindamycin remain above 0.5 μg/mL for approximately 10 hours after both IV and oral administration. Additionally, it significantly reduces oral malodor, dental plaque, dental calculus, and gingival bleeding in dogs over a period of 42 days. At a dosage of 2.5 mg/lb following ultrasonic scaling, root planing, and polishing (USRP), clindamycin significantly impacts plaque and pocket depth related to periodontal disease, though not gingivitis. Furthermore, it achieves a complete remission ratio of 71.4% (15/21) in dogs with canine superficial bacterial pyoderma within 14 to 28 days.
• In Vitro:
  Clindamycin is a classical inhibitor of bacterial protein synthesis which binds to the 23S ribosomal RNA of the 50S ribosomal subunit.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sobelin HCl, Antibiotic, Bacterial, Clinimycin HCl, Clindamycin HCl, Clindamycin hydrochloride, Clindamycin Hydrochloride, Clindamycin, Cleocin, Inhibitor, inhibit

Compound Identifiers

PubChem CID

16051951