Clifutinib

SKU: orb3028365

Description

Clifutinib (Compound 9e) is an orally active, selective inhibitor of FMS-like tyrosine kinase 3 (FLT3-ITD) with an IC50 of 15.1 nM. It inhibits FLT3-ITD kinase activity and blocks downstream signaling pathways, including RAS/MAPK, PI3K/AKT, and JAK/STAT5. Clifutinib induces apoptosis in FLT3-ITD mutated acute myeloid leukemia (AML) cells and is a potential candidate for research in relapsed/refractory FLT3-ITD positive AML.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1862226-99-0
• MW: 502.605
• Formula: C₂₉H₃₄N₄O₄
• SMILES: O=C(NC1=NOC(=C1)C(C)(C)C)NC2=CC=C(C#CC3=CC=C(OCCCN4CCOCC4)C=C3)C=C2
• Target: PI3K,JAK,Akt,p38 MAPK,Ras,Apoptosis,FLT,STAT

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PI3K,JAK,Akt,p38 MAPK,Ras,Apoptosis,FLT,STAT