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Clifutinib

SKU: orb3028365

Description

Clifutinib (Compound 9e) is an orally active, selective inhibitor of FMS-like tyrosine kinase 3 (FLT3-ITD) with an IC50 of 15.1 nM. It inhibits FLT3-ITD kinase activity and blocks downstream signaling pathways, including RAS/MAPK, PI3K/AKT, and JAK/STAT5. Clifutinib induces apoptosis in FLT3-ITD mutated acute myeloid leukemia (AML) cells and is a potential candidate for research in relapsed/refractory FLT3-ITD positive AML.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1862226-99-0
MW502.605
FormulaC29H34N4O4
SMILESO=C(NC1=NOC(=C1)C(C)(C)C)NC2=CC=C(C#CC3=CC=C(OCCCN4CCOCC4)C=C3)C=C2
TargetApoptosis,FLT,Ras,JAK,STAT,PI3K,Akt,p38 MAPK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information

Clifutinib (orb3028365)

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