Clerodendrin

SKU: orb2664839

Description

Clerodendrin is a novel neoclerodane diterpenoid, isolated from Clerodendron trichotomum leaves, which acts as an inhibitor of interleukin-4 (IL-4) and β-hexosaminidase. This dual activity makes it a candidate for research in immunology and allergy, particularly for studying Th2-mediated inflammatory responses in experimental models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 119738-57-7
• MW: 622.49
• Purity: 98.84% (May vary between batches)
• Formula: C₂₇H₂₆O₁₇
• SMILES: O=C1C=2C(OC(=C1)C3=CC=C(O)C=C3)=CC(O[C@H]4[C@H](O[C@@H]5O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O4)=CC2O
• Target: IL Receptor,Interleukin
• Solubility: DMSO:40 mg/mL(64.26 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.61 mM)

Bioactivity

• In Vitro:
  10 μM Clerodendrin treatment for 1-3 h of propidium iodide-induced RBL-2H3 cells inhibited IL-4 mRNA expression and β-hexosaminidase release.

Storage & Handling

• Storage: keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Clerodendrin, Clerodendrin (glycoside), Apigenin-7-O-glucuronopyranosyl(1-2)-glucuronopyranoside, IL Receptor, ILReceptor, IL-4, Interleukin Related, glycoside

Compound Identifiers

PubChem CID

5488004