Clazosentan

SKU: orb1685955

Description

Clazosentan (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist used in research to study ET-1-mediated vasospasm. It is applied in preclinical models of subarachnoid hemorrhage and cardiovascular diseases for both in vitro and in vivo investigations.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 180384-56-9
• MW: 577.57
• Purity: >99.99% (May vary between batches)
• Formula: C₂₅H₂₃N₉O₆S
• SMILES: COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(nc1OCCO)-c1ccnc(c1)-c1nn[nH]n1
• Target: Endothelin Receptor
• Solubility: DMSO:60 mg/mL (103.88 mM)

Bioactivity

• In Vivo:
  In Rats, Clazosentan ( 10 μM, 0.05 mL / kg ; intracisternal injection ) Inhibited the contractile responses to ET-1, without preventing SAH-induced upregulation of ET receptors in cerebral arteries.
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• In Vitro:
  Clazosentan is an effective competitive antagonist of ET ( A ) receptor-mediated ET-1 and its precursor large ET-1 on cerebral vasoconstriction.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AXV-034343, ET-A, EndothelinReceptor, Endothelin Receptor, Ro 61-1790, VML 588

Compound Identifiers

PubChem CID

6433095