CL4F8-6

SKU: orb1910462

Description

CL4F8-6 is an ionizable cationic lipid (pKa = 6.14) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs).1 LNPs containing CL4F8-6 and encapsulating an mRNA reporter accumulate specifically in the mouse liver after intravenous administration. LNPs containing CL4F8-6 and encapsulating mRNA encoding the Cas9 nuclease (mCas9) and single-guide RNA (sgRNA) targeting Ttr (sgTtr), the gene encoding transthyretin, have been used to induce CRISPR-mediated gene knockdown in mice resulting in a reduction of serum levels of TTR.

Key Properties

• CAS Number: 2766493-12-1
• MW: 808.35
• Purity: >95%
• Formula: C₅₁H₁₀₁NO₅
• SMILES: C(O)(CCCCCCOC(=O)C(CCCCCC)CCCCCC)(CCCCCCOC(=O)C(CCCCCC)CCCCCC)CCCCN(CCC)CCC

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only