CL2 Linker

SKU: orb1988542

Description

The CL2 linker is a cleavable ADC linker used to conjugate SN-38. The resulting CL2-SN-38 and CL2A-SN-38 conjugates demonstrate equivalent high drug loading, nanomolar binding affinity and cytotoxicity, and good serum stability in vitro, making them valuable tools for ADC research and preclinical development.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2270986-66-6
• MW: 1426.61
• Formula: C₆₈H₁₀₃N₁₁O₂₂
• SMILES: [C@H](CC1=CC=CC=C1)(C(N[C@H](C(NC2=CC=C(COC(N(CCN(C(OCC(CO)=O)=O)C)C)=O)C=C2)=O)CCCCNC(OC(C)(C)C)=O)=O)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCN3C=C(CNC(CCCCCN4C(=O)C=CC4=O)=O)N=N3)=O
• Target: ADC Linker,PROTAC Linker

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

139035096