CKBA

SKU: orb3173877

Description

CKBA, a derivative of AKBA, acts as an acetyl-CoA carboxylase 1 (ACC1) inhibitor with an IC50 of 5.02 μM. It inhibits Th17 cell differentiation, displaying IC50 values of 3.28 μM in mouse cells and 3.61 μM in human cells. CKBA ointment significantly alleviates psoriasis-like inflammation in mice and can be used for psoriasis research.

Key Properties

• CAS Number: 1786406-66-3
• MW: 580.85
• Formula: C₃₇H₅₆O₅
• SMILES: C[C@]12[C@@]([C@]3(C)[C@@](CC1)([C@](C(O)=O)(C)[C@H](OC(=O)C4CCCCC4)CC3)[H])(C(=O)C=C5[C@@]2(C)CC[C@]6(C)[C@]5([C@@H](C)[C@H](C)CC6)[H])[H]
• Target: Acetyl-CoA Carboxylase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Acetyl-CoA Carboxylase