CK2/ERK8-IN-1

SKU: orb1710039

Description

CK2/ERK8-IN-1 (TMCB) is a potent, dual inhibitor of CK2 and ERK8 kinases, also binding to PIM1, DYRK1A, and HIPK2. It demonstrates pro-apoptotic activity, making it a valuable chemical probe for studying kinase signaling in cancer research and apoptosis assays in vitro.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1085822-09-8
• MW: 534.82
• Purity: 98.82% (May vary between batches)
• Formula: C₁₁H₉Br₄N₃O₂
• SMILES: CN(C)c1nc2c(Br)c(Br)c(Br)c(Br)c2n1CC(O)=O
• Target: Apoptosis,DYRK,Pim,Casein Kinase,ERK
• Solubility: DMSO:1 mg/mL (1.87 mM)

Bioactivity

• Target IC50:
  Apoptosis:|Pim1:8.65 μM (ki)|DYRK1A:11.9 μM (ki)|HIPK2:15.25 μM (ki)|CK2:0.25 μM (ki)|CK2:0.5 μM|ERK8:0.5 μM
• In Vitro:
  In Jurkat cells, CK2/ERK8-IN-1 (Compound K66; 0-50 µM; 24 hours) treatment displays cytotoxic activity.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ERK, ERK8, HIPK2, Casein Kinase, CaseinKinase, Apoptosis, CK2, CK2/ERK8-IN-1, DYRK1A, TMCB, PIM1

Compound Identifiers

PubChem CID

46943415