CJ-42794

SKU: orb1308446

Description

CJ-42794 is a potent and selective antagonist of the human prostaglandin E receptor EP4, exhibiting a pKi of 8.5 and over 200-fold selectivity versus other EP subtypes. This tool compound is used in both in vitro and in vivo research to investigate EP4-mediated pathways in inflammation, cancer, and pain.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 847728-01-2
• MW: 413.83
• Purity: 99.92% (May vary between batches)
• Formula: C₂₂H₁₇ClFNO₄
• SMILES: C[C@H](NC(=O)c1cc(Cl)ccc1Oc1ccc(F)cc1)c1ccc(cc1)C(O)=O
• Target: Prostaglandin Receptor,Others
• Solubility: DMSO:28 mg/mL (67.66 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.83 mM)

Bioactivity

• Target IC50:
  EP4 receptor:10 nM (EC50)
• In Vivo:
  CJ-42794 significantly delays ulcer healing in rats and mice and these responses were both attenuated by coadministration of CJ-42794 .
• In Vitro:
  CJ-042794 competitively inhibits PGE2-evoked elevations of intracellular cAMP levels in HEK293 cells overexpressing human EP4receptor (mean pA2: 8.6). CJ-042794 reverses the inhibitory effects of PGE2 on LPS-induced TNFα production in a concentration-dependent manner .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Progesterone Receptor, prostaglandin E2, tumor necrosis factor α, human whole blood, Inhibitor, gastric ulcers, inhibit, NR3C3, CJ42794, CJ-42794, CJ 042794, CJ 42794, CJ042794, CJ-042794, cAMP

Compound Identifiers

PubChem CID

11524454