cis-THSG

SKU: orb3212101

Description

cis-THSG is an orally active and selective inhibitor of DNA topoisomerase II (DNAtopoisomeraseII), with no inhibitory activity against DNA topoisomerase I. It can inhibit the transcriptional expression of phosphoenolpyruvate carboxykinase (PEPCK). cis-THSG lowers blood glucose levels in male CF-1 mice with diet-induced diabetes, improves glucose intolerance, and alleviates insulin resistance. It is applicable in research related to type 2 diabetes.

Key Properties

• CAS Number: 928205-59-8
• MW: 406.38
• Formula: C₂₀H₂₂O₉
• SMILES: O(C1=C(/C=C\C2=CC=C(O)C=C2)C=C(O)C=C1O)[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O
• Target: Topoisomerase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Topoisomerase