cis-22a

SKU: orb1690048

Description

Cis-22a is a selective TRPV6 channel inhibitor (IC50 = 0.32 µM) with demonstrated antiproliferative activity against T47D breast cancer cells in vitro. It shows selectivity over related TRPV channels and other calcium channels, making it a useful research tool for studying TRPV6's role in cellular proliferation and calcium signaling pathways.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1819366-84-1
• MW: 449.51
• Purity: 99.99% (May vary between batches)
• Formula: C₂₄H₃₀F₃N₃O₂
• SMILES: C(C(O)=O)(F)(F)F.CC=1C=C([C@H]2CC[C@H](CC2)N3CCN(CC3)C=4C=CC=NC4)C=CC1
• Target: TRP/TRPV Channel,Calcium Channel
• Solubility: DMSO:90 mg/mL (200.22 mM);H2O:90 mg/mL (200.22 mM)

Bioactivity

• Target IC50:
  TRPV6:0.32 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cis 22a, cis22a, Cis-22a, CalciumChannel, Calcium Channel, TRPV6, TRPVChannel, TRPChannel, TRPV Channel, TRP Channel

Compound Identifiers

PubChem CID

169553405