Cirazoline hydrochloride

SKU: orb1707443

Description

Cirazoline hydrochloride is a synthetic α1-adrenergic receptor ligand, acting as a full agonist at α1A-AR (Ki=120 nM) and a partial agonist at α1B- and α1D-AR subtypes. It is a valuable pharmacological tool for investigating vascular physiology, adrenergic signaling mechanisms, and cardiovascular function in both in vitro and in vivo research models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 40600-13-3
• MW: 252.74
• Purity: 99.86% (May vary between batches)
• Formula: C₁₃H₁₇ClN₂O
• SMILES: Cl.N1=C(NCC1)COC=2C=CC=CC2C3CC3
• Target: Adrenergic Receptor,Adenosine Receptor
• Solubility: H2O:24 mg/mL (94.96 mM)

Bioactivity

• Target IC50:
  AR-α1D:660 nM (Ki)|AR-α1A:120 nM (Ki)|AR-α1B:960 nM (Ki)
• In Vivo:
  Methods: B6/CBA mice were treated with Cirazoline hydrochloride (drinking water, 40 μM, for 9 months) to investigate the influence of α1A-AR signaling in antidepressant effects. Results: Wild-type mice with long-term intake of Cirazoline hydrochloride showed a significant reduction in immobility time during the TST (tail suspension test). .
• In Vitro:
  Methods: Glioblastoma-initiating cells were treated with cirazoline hydrochloride (5-10 μM, 24 hours), and cell viability was measured using the WST-1 reduction assay. Results: Cirazoline hydrochloride did not alter the viability of GICs and only slightly antagonized prazosin-induced GIC death.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cirazoline Hydrochloride, LD3098 hydrochloride, LD-3098 Hydrochloride

Compound Identifiers

PubChem CID

11957512