Cinnarizine

SKU: orb1310183

Description

Cinnarizine

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 298-57-7
• MW: 368.51
• Purity: 100.00%
• Formula: C₂₆H₂₈N₂
• SMILES: C(\C=C\C1=CC=CC=C1)N1CCN(CC1)C(C1=CC=CC=C1)C1=CC=CC=C1
• Target: Histamine Receptor,Calcium Channel
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:6.25 mg/mL (16.96 mM)

Bioactivity

• In Vivo:
  Cinnarizine has anticonvulsive properties in rats and mice. It could provide a Direct neur Protective effect agains the damaging influx of calcium and also prevent neuronal damage as a result of MES- and PTZ-induced seizure. Cinnarizine induces behavioural Changes such as alopecia, bucolingual dyskinesia and reduction of motor activity in f Male parkin knock out (PK-KO) mice but not in wild-type (WT) controls.PK-KO mice have high striatal dopamine levels and increased dopamine metabolism in spite of low reduced tyrosine hydroxylase protein. Cinnarizine, which blocks dopamine receptors and increases dopamine release, further increased dopamine metabolis. Its half-life is 4 hours.
• In Vitro:
  Cinnarizine inhibits melanogenesis in B16 cells by a dose-dependent manner a the non-cytotoxic concentration and is a histamine receptor antagonist.
• Cell Research:
  MTT assay is performed to examin the viability of cells. Afterwards the cells are incubated wit the Samples for 48 h the culture medium is removed and replaced with 1 mg mL MTT solution dissolved in phosphate-buffered saline (PBS) and incubated for an additional 2 h the MTT solution is then removed and DMSO was added, following whic the absorbance o the dissolved formazan crystals is determined at 570 nM by a spectrophotometer.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Dimitronal, CalciumChannel, Cinarizine, Cinnarizine, Calcium Channel, Ca2+ channels, Ca channels, H1 receptor, HistamineReceptor, Histamine Receptor, inhibit, Inhibitor, Stugeron, Stutgin

Compound Identifiers

PubChem CID

1547484