Cinnarizine

SKU: orb1310183

Description

Cinnarizine is a piperazine-based small molecule with dual histamine H1-receptor antagonism and calcium-channel blocking activities, leading to vasodilation and antiemetic effects. It is utilized in research on vestibular disorders and motion sickness, though its use is associated with inducing extrapyramidal symptoms like parkinsonism in clinical settings.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 298-57-7
• MW: 368.51
• Purity: >99.99% (May vary between batches)
• Formula: C₂₆H₂₈N₂
• SMILES: C(\C=C\C1=CC=CC=C1)N1CCN(CC1)C(C1=CC=CC=C1)C1=CC=CC=C1
• Target: Histamine Receptor,Calcium Channel
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:6.25 mg/mL (16.96 mM)

Bioactivity

• In Vivo:
  Cinnarizine has anticonvulsive properties in rats and mice. It could provide a direct neuroprotective effect against the damaging influx of calcium and also prevent neuronal damage as a result of MES- and PTZ-induced seizures. Cinnarizine induces behavioural changes such as alopecia, bucolingual dyskinesia and reduction of motor activity in female parkin knock out (PK-KO) mice but not in wild-type (WT) controls.PK-KO mice have high striatal dopamine levels and increased dopamine metabolism in spite of low reduced tyrosine hydroxylase protein. Cinnarizine, which blocks dopamine receptors and increases dopamine release, further increased dopamine metabolism. Its half-life is 4 hours.
• In Vitro:
  Cinnarizine inhibits melanogenesis in B16 cells by a dose-dependent manner at the non-cytotoxic concentrations and is a histamine receptor antagonists.
• Cell Research:
  MTT assay is performed to examine the viability of cells. Afterwards, the cells are incubated with the samples for 48 h, the culture medium is removed and replaced with 1 mg/mL MTT solution dissolved in phosphate-buffered saline (PBS) and incubated for an additional 2 h. The MTT solution is then removed and DMSO was added, following which the absorbance of the dissolved formazan crystals is determined at 570 nm by a spectrophotometer.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dimitronal, CalciumChannel, Cinarizine, Cinnarizine, Calcium Channel, Ca2+ channels, Ca channels, H1 receptor, HistamineReceptor, Histamine Receptor, inhibit, Inhibitor, Stugeron, Stutgin

Compound Identifiers

PubChem CID

1547484