Cinnamic acid

SKU: orb1301623

Description

Cinnamic acid

Research Area

Metabolism Research

Key Properties

• CAS Number: 621-82-9
• MW: 148.16
• Purity: 99.74%
• Formula: C₉H₈O₂
• SMILES: O=C(O)C=CC=1C=CC=CC1
• Target: Endogenous Metabolite
• Solubility: Ethanol:50 mg/mL (337.47 mM)

Bioactivity

• In Vivo:
  Oinnamic acid exerts anti-diabetic activity by improving glucose tolerance in vivo and stimulating insulin secretion in vitro.
• Animal Research:
  Non-obese type 2 diabetes was developed by injecting 90 mg/kg streptozotocin in 2-day-old Wistar pups. Cinnamic acid and cinnamaldehyde were administered orally to diabetic rats for assessing acute blood glucose lowering effect and improvement of glucose tolerance. Additionally, insulin secretory activity of cinnamic acid and cinnamaldehyde was evaluated in isolated mice islets. Cinnamic acid, but not cinnamaldehyde, decreased blood glucose levels in diabetic rats in a time- and dose-dependent manner. Oral administration of cinnamic acid with 5 and 10 mg/kg doses to diabetic rats improved glucose tolerance in a dose-dependent manner. The improvement by 10 mg/kg cinnamic acid was comparable to that of standard drug glibenclamide (5 mg/kg).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

β-Phenylacrylic acid, Cinnamic acid, beta-Phenylacrylic acid, b-Phenylacrylic acid, 3-Phenylacrylic acid, inhibit, Inhibitor, EndogenousMetabolite, Endogenous Metabolite

Compound Identifiers

PubChem CID

8784