Cinchonidine

SKU: orb1309005

Description

Cinchonidine is a natural alkaloid isolated from Cinchona officinalis and serves as a pseudo-enantiomer of cinchonine. This small molecule is utilized in asymmetric synthesis research and has been investigated in vitro for its potential biological activities.

Research Area

Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 485-71-2
• MW: 294.39
• Purity: 99.87%
• Formula: C₁₉H₂₂N₂O
• SMILES: [C@H](O)([C@]1([N@@]2C[C@H](C=C)[C@](C1)(CC2)[H])[H])C=3C4=C(N=CC3)C=CC=C4
• Target: Parasite,Serotonin Transporter,5-HT Receptor
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:8.57 mg/mL (29.11 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.4 mM);Ethanol:55 mg/mL (186.83 mM)

Bioactivity

• Target IC50:
  sEH:4.2 μM (Ki)|dSERT:330 μM (Ki)|SERT Y95F (human):15 μM (Ki)|SERT I172M (human):36 μM (Ki)|SERT S438T (human):196 μM (Ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

a-Quinidine, 5HT Receptor, 5HTReceptor, alpha-Quinidine, Cinchonidine, L-Cinchonidine, Parasite, SERT, SerotoninTransporter, Serotonin Transporter, α-Quinidine

Compound Identifiers

PubChem CID

101744