Cilofexor

SKU: orb1299821

Description

Cilofexor is a potent and selective farnesoid X receptor (FXR) agonist. It functions by binding to and activating FXR, thereby inhibiting the interaction with synthetic peptide ligands. This small molecule is utilized in research on metabolic and liver diseases, including in vitro assays and in vivo models of cholestasis and NASH.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 1418274-28-8
• MW: 586.85
• Purity: 99.86% (May vary between batches)
• Formula: C₂₈H₂₂Cl₃N₃O₅
• SMILES: OC(=O)c1ccnc(c1)N1CC(O)(C1)c1ccc(OCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)cc1Cl
• Target: Autophagy,FXR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.82 mM);DMSO:125 mg/mL (213 mM)

Bioactivity

• Target IC50:
  FXR:43 nM (EC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antifibrotic, anti-inflammatory, Autophagy, Cilofexor, GS9674, GS-9674, GS 9674, FXR, inhibit, Inhibitor, NR1H4, nonsteroidal, oral, NASH, safety, PSC

Compound Identifiers

PubChem CID

71228883