Ciglitazone

SKU: orb1705997

Description

Ciglitazone

Research Area

Cell Biology, Metabolism Research, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 74772-77-3
• MW: 333.45
• Purity: 99.59%
• Formula: C₁₈H₂₃NO₃S
• SMILES: CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1
• Target: PPAR,Apoptosis,p38 MAPK
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (9.9 mM);DMSO:90 mg/mL (269.91 mM)

Bioactivity

• Target IC50:
  PPARγ:3 μM(EC50)
• In Vivo:
  Ciglitazone (100 mg/kg/day ; 2 days ; C57BL/6J-ob/ob mice) elicits a drastic All in blood glucose Ciglitazone (100 mg/kg/day ; 41-44 days ; ob/ob mice) degranulation of islet beta-cells and increased pancreatic Insulin content are observed
• In Vitro:
  Ciglitazone (0-20 μM ; 24 hours) ciglitazone cause the generation of ROS and an increase in intracellular Ca2+ and induces apoptosis through a PPAR-independent mechanism

Storage & Handling

• Storage: store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

U 63287, U63287, U-63287, PPARγ, p38MAPK, p38 MAPK, Ciglitazona, Ciglitazone, Apoptosis, ADD3878, ADD-3878, ADD 3878, AIF

Compound Identifiers

PubChem CID

2750