Ciglitazone

SKU: orb1705997

Description

Ciglitazone

Research Area

Cardiovascular Research, Neuroscience, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 74772-77-3
• MW: 333.5
• Purity: >98%
• Formula: C₁₈H₂₃NO₃S
• SMILES: CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1
• Target: Transcription factor
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).

Bioactivity

• Target IC50:
  PPARγ:3 μM(EC50)
• In Vivo:
  Ciglitazone (100 mg/kg/day ; 2 days ; C57BL/6J-ob/ob mice) elicits a drastic fall in blood glucose. Ciglitazone (100 mg/kg/day ; 41-44 days ; ob/ob mice) degranulation of islet beta-cells and increased pancreatic insulin content are observed.
• In Vitro:
  Ciglitazone (0-20 μM ; 24 hours) ciglitazone causes the generation of ROS and an increase in intracellular Ca2+ and induces apoptosis through a PPAR-independent mechanism.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

U 63287, U63287, U-63287, PPARγ, p38MAPK, p38 MAPK, Ciglitazona, Ciglitazone, Apoptosis, ADD3878, ADD-3878, ADD 3878, AIF

Compound Identifiers

PubChem CID

2750