Cidofovir

SKU: orb1300943

Description

Cidofovir ((S)-HPMPC) is an antiviral nucleotide analog that selectively inhibits viral DNA polymerase, thereby suppressing viral DNA replication. It is widely used in research to study DNA virus infections, including cytomegalovirus and poxviruses, in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 113852-37-2
• MW: 279.19
• Purity: 99.76% (May vary between batches)
• Formula: C₈H₁₄N₃O₆P
• SMILES: Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1
• Target: DNA/RNA Synthesis
• Solubility: H2O:5 mg/mL (17.91 mM);DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Cidofovir (5 mg/kg/day) subcutaneously for 5 days significantly reduces average virus infectivity titer in blood, spleen, lung and salivary gland in infected guinea pigs. Cidofovir significantly reduces lymphocytosis and average tissue indexe of spleen in infected animals. . Cidofovir suppresses all manifestations (skin lesions, paralysis of the hind legs, and mortality) of hairless mice infected intracutaneously with HSV-1 or HSV-2. The most remarkable feature of Cidofovir is that a single administration of the compound, even as late as 4 days after infection, conferees significant protection against HSV-1 or HSV-2 infection. Cidofovir inhibits growth of the highly aggressive melanoma tumor arising from mouse melanoma B16 cells grafted subcutaneously in C57B16/J mice.
  Read more...
• In Vitro:
  Cidofovir inhibits human cytomegalovirus (HCMV) infection in cultured cells. Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively. Cidofovir also inhibits herpes simplex virus infection. In addition, Cidofovir blocks cell fusion induced by HSV-1 in monkey kidney cells and blocks the expression of HSV-l-specific proteins and the synthesis of viral DNA.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(S)-HPMPC, cancer, antiviral, Apoptosis, CMV, Cidofovir, DNA/RNA Synthesis, DNA Synthesis, DNASynthesis, Cytomegalovirus, GS 0504, GS0504, GS-0504, Endogenous Metabolite, herpes, HPMPC, Orthopoxvirus, Inhibitor, inhibit, retinitis, RNA Synthesis, RNASynthesis

Compound Identifiers

PubChem CID

60613