CID44216842

SKU: orb1219020

Description

CID44216842 is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 0.3 and 0.5 μM in GDP binding assay, respectively. Use as a molecular probe.

Key Properties

• CAS Number: 1222513-26-9
• MW: 486.38
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₀BrN₃O₃S
• SMILES: O=S(C1=CC=C(N2N=C(C3=CC=CC(OC)=C3)CC2C4=CC=C(Br)C=C4)C=C1)(N)=O
• Target: CDK
• Solubility: DMSO:250 mg/mL (514.00 mM; Need ultrasonic)

Bioactivity

• In Vitro:
  CID44216842 inhibits GTP binding to both Cdc42 and its mutant in a dose-dependent manner. The inhibition is specific toward Cdc42 with no effects on other GTPases including Rac and Rho in the same family.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KUC103479N-02

Quick Database Links

Gene Symbol

CDK