CID 5951923

SKU: orb1305857

Description

CID 5951923 is a potent small molecule inhibitor of the KLF5 transcription factor, exhibiting an IC50 value of 603 nM. This compound is a valuable research tool for investigating KLF5 function in cancer biology and other fields, with utility in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 749872-43-3
• MW: 382.39
• Purity: 100.00% (May vary between batches)
• Formula: C₁₆H₁₈N₂O₇S
• SMILES: CN(C1CCS(=O)(=O)C1)C(=O)COC(=O)\C=C\c1cccc(c1)[N+]([O-])=O
• Target: DNA/RNA Synthesis
• Solubility: DMSO:3.83 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  KLF5:603 nM (IC50)
• In Vitro:
  CID 5951923 (10 μM) inhibits the proliferation of cancer cell lines mainly in highly expressing KLF5 cells. CID 5951923 (0.001, 0.01, 0.1, 1, 10, 100 μM) inhibits proliferation of DLD-1 cells in a dose-dependent manner. CID 5951923 (10 μM) significantly decreases endogenous KLF5 levels in the DLD-1 cells, downregulates EGR1, and increases phosphorylation levels of pEGFFpY1068.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNASynthesis, DNA Synthesis, CID 5951923, CID-5951923, CID5951923, cancer, factor, Inhibitor, inhibit, KLF, KLF5, Krüppel-like, Krüppel-like factor, RNASynthesis, RNA Synthesis, transcription

Compound Identifiers

PubChem CID

5951923